PKC zeta Antikörper

Produktnummer ABIN7008643

Produktdetails anti-PKC zeta Antikörper

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC zeta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human PRKCZ (NP_002735.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PKC zeta

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Andere Bezeichnung: PRKCZ (PRKCZ Produkte)

Synonyme: TPKC antikoerper, PKCzeta antikoerper, prkcz-A antikoerper, pkc-zeta antikoerper, PRKCZ antikoerper, pkc2 antikoerper, PKC-ZETA antikoerper, PKC2 antikoerper, AI098070 antikoerper, C80388 antikoerper, Pkcz antikoerper, R74924 antikoerper, aPKCzeta antikoerper, zetaPKC antikoerper, 14-3-3-zetaisoform antikoerper, r14-3-3 antikoerper, pkcz antikoerper, si:ch211-150o23.4 antikoerper, protein kinase C zeta L homeolog antikoerper, protein kinase C zeta antikoerper, protein kinase C, zeta antikoerper, prkcz.L antikoerper, PRKCZ antikoerper, prkcz antikoerper, Prkcz antikoerper

Hintergrund: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht:

Observed_MW: 78 kDa

Calculated_MW: 46 kDa/56 kDa/67 kDa

Gen-ID: 5590

UniProt: Q05513

Pathways: NF-kappaB Signalweg, RTK Signalweg, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling