Dual Specificity Phosphatase 3 (DUSP3) Antikörper

Produktnummer ABIN7255902

Produktdetails

Target: Dual Specificity Phosphatase 3 (DUSP3)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human DUSP3 (NP_004081.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: Dual Specificity Phosphatase 3 (DUSP3)

Andere Bezeichnung: DUSP3 (DUSP3 Produkte)

Synonyme: dusp3 antikoerper, si:bz18k17.3 antikoerper, si:rp71-18k17.3 antikoerper, VHR antikoerper, RGD1560049 antikoerper, 2210015O03Rik antikoerper, 5031436O03Rik antikoerper, T-DSP11 antikoerper, dual specificity phosphatase 3 antikoerper, dual specificity phosphatase 3b antikoerper, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) antikoerper, DUSP3 antikoerper, dusp3b antikoerper, Dusp3 antikoerper

Substanzklasse: Viral Protein

Hintergrund: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Molekulargewicht:

Observed_MW: 20 kDa

Calculated_MW: 16 kDa/20 kDa

Gen-ID: 1845

UniProt: P51452

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades