GRIA2 Antikörper

Produktnummer ABIN7242353

Produktdetails anti-GRIA2 Antikörper

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIA2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human GRIA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Andere Bezeichnung: GluR2 (GRIA2 Produkte)

Synonyme: GLUR2 antikoerper, GLURB antikoerper, GluA2 antikoerper, GluR-K2 antikoerper, HBGR2 antikoerper, GluR-2 antikoerper, GluR-B antikoerper, Glur-2 antikoerper, Glur2 antikoerper, GluR2 antikoerper, gluR-B antikoerper, glur2a antikoerper, gria2.1 antikoerper, zfGRIA2[a] antikoerper, glur2 antikoerper, glutamate ionotropic receptor AMPA type subunit 2 antikoerper, glutamate receptor, ionotropic, AMPA 2 antikoerper, glutamate receptor, ionotropic, AMPA2 (alpha 2) antikoerper, glutamate receptor, ionotropic, AMPA 2a antikoerper, glutamate receptor, ionotropic, AMPA 2 S homeolog antikoerper, GRIA2 antikoerper, Gria2 antikoerper, gria2a antikoerper, gria2.S antikoerper

Hintergrund: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

NCBI Accession: NP_000817

UniProt: P42262

Pathways: PI3K-Akt Signalweg