LRRC8A Antikörper (N-Term)

Produktnummer ABIN6992155

Produktdetails anti-LRRC8A Antikörper

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Bindungsspezifität: AA 60-110, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRC8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: LRRC8A antibody is human, mouse and rat reactive.

Aufreinigung: LRRC8A antibody is affinity chromatography purified via peptide column.

Immunogen: LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is located within amino acids 60 - 110 of LRRC8A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: LRRC8A antibody can be used for detection of LRRC8A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LRRC8A antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LRRC8A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu LRRC8A

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Andere Bezeichnung: LRRC8A (LRRC8A Produkte)

Synonyme: AGM5 antikoerper, LRRC8 antikoerper, Lrrc8 antikoerper, mKIAA1437 antikoerper, wu:fb18g12 antikoerper, wu:fi21b10 antikoerper, LLRC8A antikoerper, leucine rich repeat containing 8 VRAC subunit A antikoerper, leucine rich repeat containing 8A antikoerper, leucine rich repeat containing 8 VRAC subunit Aa antikoerper, leucine-rich repeat containing 8 family member A S homeolog antikoerper, leucine rich repeat containing 8 family member A antikoerper, LRRC8A antikoerper, Lrrc8a antikoerper, lrrc8aa antikoerper, lrrc8a.S antikoerper

Hintergrund: The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2). LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1). LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3).

Molekulargewicht: Predicted: 89 kDa

Observed: 95 kDa

Gen-ID: 56262

NCBI Accession: NP_062540

UniProt: Q8IWT6