LXR-B Antibody is affinity chromatography purified via peptide column.
Immunogen
LXR-B antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B. The immunogen is located within the first 50 amino acids of LXR-B.
LXR-B antibody can be used for detection of LXR-B by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
LXR-B Antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
LXR-B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
NR1H2
(Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))
NR1H2 antikoerper, lxr-b antikoerper, lxrb antikoerper, ner antikoerper, ner-i antikoerper, rip15 antikoerper, unr antikoerper, DKFZp468A0622 antikoerper, AI194859 antikoerper, LXR antikoerper, LXRB antikoerper, LXRbeta antikoerper, NER1 antikoerper, OR-1 antikoerper, RIP15 antikoerper, UR antikoerper, Unr antikoerper, Unr2 antikoerper, LXR-b antikoerper, NER antikoerper, NER-I antikoerper, UNR antikoerper, nuclear receptor subfamily 1 group H member 2 antikoerper, nuclear receptor subfamily 1, group H, member 2 antikoerper, nuclear receptor subfamily 1 group H member 2 L homeolog antikoerper, NR1H2 antikoerper, nr1h2 antikoerper, Nr1h2 antikoerper, nr1h2.L antikoerper
Hintergrund
LXR-B Antibody: LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.