SKA3 Antikörper (C-Term)

Produktnummer ABIN6991192

Produktdetails anti-SKA3 Antikörper

Target: SKA3 (Spindle and Kinetochore Associated Complex Subunit 3 (SKA3))

Bindungsspezifität: AA 290-340, C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKA3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: SKA3 Antibody is affinity chromatography purified via peptide column.

Immunogen: SKA3 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human SKA3. The immunogen is located within amino acids 290 - 340 of SKA3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SKA3 antibody can be used for detection of SKA3 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SKA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SKA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SKA3

Target: SKA3 (Spindle and Kinetochore Associated Complex Subunit 3 (SKA3))

Andere Bezeichnung: SKA3 (SKA3 Produkte)

Synonyme: C13orf3 antikoerper, RAMA1 antikoerper, RGD1307201 antikoerper, C12H13ORF3 antikoerper, fc23d11 antikoerper, si:rp71-68n21.13 antikoerper, wu:fc23d11 antikoerper, rama1 antikoerper, F630043A04Rik antikoerper, spindle and kinetochore associated complex subunit 3 antikoerper, spindle and kinetochore associated complex subunit 3 L homeolog antikoerper, SKA3 antikoerper, Ska3 antikoerper, ska3 antikoerper, ska3.L antikoerper

Hintergrund: SKA3 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.

Gen-ID: 221150

NCBI Accession: NP_659498

UniProt: Q8IX90