APH1A Antikörper (AA 80-130)

Produktnummer ABIN6990700

Produktdetails anti-APH1A Antikörper

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Bindungsspezifität: AA 80-130

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APH1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: APH1 Antibody is affinity chromatography purified via peptide column.

Immunogen: APH1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human APH1. The immunogen is located within amino acids 80 - 130 of APH1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: APH1 antibody can be used for detection of APH1 by Western blot at 0.5 - 1 μ,g/mL. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: APH1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: APH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu APH1A

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Andere Bezeichnung: APH1 (APH1A Produkte)

Synonyme: 6530402N02Rik antikoerper, APH-1 antikoerper, APH-1A antikoerper, CGI-78 antikoerper, RGD1311546 antikoerper, APH-1a antikoerper, aph-1 homolog A, gamma-secretase subunit antikoerper, aph-1 homolog A, gamma secretase subunit L homeolog antikoerper, aph-1 homolog A, gamma secretase subunit antikoerper, anterior pharynx defective 1 homolog A (C. elegans) antikoerper, aph1 homolog A, gamma secretase subunit antikoerper, acylamino-acid-releasing enzyme-like antikoerper, APH1A antikoerper, aph1a.L antikoerper, Aph1a antikoerper, LOC100219182 antikoerper

Hintergrund: APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.

Molekulargewicht: Predicted: 29 kDa

Observed: 28 kDa

Gen-ID: 51107

UniProt: Q96BI3

Pathways: Notch Signalweg, Neurotrophin Signalübertragung