DcR2 Antikörper (AA 230-280)

Produktnummer ABIN6990272

Produktdetails anti-DcR2 Antikörper

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Bindungsspezifität: AA 230-280

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DcR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: DcR2 Antibody is affinity chromatography purified via peptide column.

Immunogen: DcR2 antibody was raised against a 15 amino acid peptide near the center of human DcR2. The immunogen is located within amino acids 230 - 280 of DcR2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL and Immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DcR2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DcR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Andere Bezeichnung: DcR2 (TNFRSF10D Produkte)

Synonyme: TNFRSF10D antikoerper, CD264 antikoerper, DCR2 antikoerper, TRAIL-R4 antikoerper, TRAILR4 antikoerper, TRUNDD antikoerper, TNF receptor superfamily member 10d antikoerper, tumor necrosis factor receptor superfamily member 10D antikoerper, TNFRSF10D antikoerper, LOC716901 antikoerper

Hintergrund: DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

Molekulargewicht: Predicted: 36 kDa

Observed: 36 kDa

Gen-ID: 8793

UniProt: Q9UBN6

Pathways: Apoptose