DcR2 Antikörper (AA 1-210) (APC)

Produktnummer ABIN6240814

Produktdetails anti-DcR2 Antikörper (APC)

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Bindungsspezifität: AA 1-210

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DcR2 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Spezifität: The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Klon: TRAIL-R4-01

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Kommentare:

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Andere Bezeichnung: CD264 / TRAIL-R4 (TNFRSF10D Produkte)

Synonyme: TNFRSF10D antikoerper, CD264 antikoerper, DCR2 antikoerper, TRAIL-R4 antikoerper, TRAILR4 antikoerper, TRUNDD antikoerper, TNF receptor superfamily member 10d antikoerper, tumor necrosis factor receptor superfamily member 10D antikoerper, TNFRSF10D antikoerper, LOC716901 antikoerper

Hintergrund: TNF receptor superfamily member 10d,TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).,TNFRSF10D, DcR2, TRUNDD, TRAILR4

Gen-ID: 8793

UniProt: Q9UBN6

Pathways: Apoptose