RPS6KA1 Antikörper (AA 51-150) (AbBy Fluor® 750)

Produktnummer ABIN6981609

Produktdetails anti-RPS6KA1 Antikörper (AbBy Fluor® 750)

Target: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Bindungsspezifität: AA 51-150

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS6KA1 Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RPS6KA1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RPS6KA1

Target: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Andere Bezeichnung: RPS6KA1 (RPS6KA1 Produkte)

Synonyme: HU-1 antikoerper, MAPKAPK1A antikoerper, RSK antikoerper, RSK1 antikoerper, Rsk1 antikoerper, p90rsk antikoerper, rsk antikoerper, RPS6KA antikoerper, hu-1 antikoerper, mapkapk1a antikoerper, rsk1 antikoerper, wu:fc56h07 antikoerper, zgc:152654 antikoerper, ribosomal protein S6 kinase A1 antikoerper, ribosomal protein S6 kinase polypeptide 1 antikoerper, ribosomal protein S6 kinase A1-like antikoerper, ribosomal protein S6 kinase A1 L homeolog antikoerper, ribosomal protein S6 kinase a, polypeptide 1 antikoerper, RPS6KA1 antikoerper, Rps6ka1 antikoerper, RPS6KA1L antikoerper, rps6ka1.L antikoerper, rps6ka1 antikoerper

Hintergrund:

Synonyms: RSK1 p90, 90 kDa ribosomal protein S6 kinase 1, dJ590P13.1 (ribosomal protein p90RSK, RSK1 p90, S6 kinase, 90kD, polypeptide 1, dJ590P13.1, EC 2.7.11.1, HU 1, HU1, KS6A1_HUMAN, MAP kinase activated protein kinase 1a, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1A, MAPKAPK-1a, MAPKAPK1A, MGC79981, Mitogen-activated protein kinase-activated protein kinase 1A, OTTHUMP00000004113, p90 RSK1, p90-RSK 1, p90rsk, p90RSK1, p90S6K, pp90RSK1, Ribosomal protein S6 kinase 90kD 1, Ribosomal protein S6 kinase 90kD polypeptide 1, Ribosomal protein S6 kinase 90 kDa polypeptide 1, Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha-1, Ribosomal protein S6 kinase polypeptide 1, Ribosomal S6 kinase 1, RPS6K1 alpha, rps6ka, Rps6ka1, RSK 1, RSK 1 p90, RSK, RSK-1, RSK1, S6K alpha 1, S6K-alpha-1.

Background: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

Gen-ID: 6195

UniProt: Q15418

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades