HLA-DRB3 Antikörper

Produktnummer ABIN6939646

Produktdetails anti-HLA-DRB3 Antikörper

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Reaktivität: Human, Affe, Pavian, Schimpanse, Hund, Eichhörnchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-DRB3 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Spezifität: This MAb reacts with the HLA-DRB3 antigen, a member of MHC class II molecules.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

Aufreinigung: Purified by Protein A/G

Immunogen: Human REH cells (non-T, non-B leukemia cell line)

Klon: Bra30

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu HLA-DRB3

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Andere Bezeichnung: HLA-DRB3 (HLA-DRB3 Produkte)

Synonyme: HLA-DR3B antikoerper, BLA-DRB3 antikoerper, Bota-DRB01 antikoerper, Bota-DRB02 antikoerper, Bota-DRB04 antikoerper, Bota-DRB07 antikoerper, Bota-DRB21 antikoerper, Bota-DRB22 antikoerper, LA-DRB antikoerper, major histocompatibility complex, class II, DR beta 3 antikoerper, major histocompatibility complex, class II, DRB3 antikoerper, HLA-DRB3 antikoerper, BOLA-DRB3 antikoerper

Molekulargewicht: ~28kDa (beta chain)

Gen-ID: 3123

UniProt: P01911

Pathways: T-Zell Rezeptor Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints