HLA-DRB3 Antikörper (AA 30-227)
-
- Target Alle HLA-DRB3 Antikörper anzeigen
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
-
Bindungsspezifität
- AA 30-227
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser HLA-DRB3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- GDTRPRFLEL RKSECHFFNG TERVRYLDRY FHNQEEFLRF DSDVGEYRAV TELGRPVAES WNSQKDLLEQ KRGRVDNYCR HNYGVGESFT VQRRVHPQVT VYPAKTQPLQ HHNLLVCSVS GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN GDWTFQTLVM LETVPRSGEV YTCQVEHPSV TSALTVEWRA RSESAQSK
- Kreuzreaktivität
- Human, Maus, Ratte
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB3 (NP_072049.2).
- Isotyp
- IgG
- Top Product
- Discover our top product HLA-DRB3 Primärantikörper
-
-
- Applikationshinweise
- WB,1:500 - 1:2000
- Kommentare
-
HIGH QUALITY
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- Andere Bezeichnung
- HLA-DRB3 (HLA-DRB3 Produkte)
- Synonyme
- HLA-DR3B antikoerper, BLA-DRB3 antikoerper, Bota-DRB01 antikoerper, Bota-DRB02 antikoerper, Bota-DRB04 antikoerper, Bota-DRB07 antikoerper, Bota-DRB21 antikoerper, Bota-DRB22 antikoerper, LA-DRB antikoerper, major histocompatibility complex, class II, DR beta 3 antikoerper, major histocompatibility complex, class II, DRB3 antikoerper, HLA-DRB3 antikoerper, BOLA-DRB3 antikoerper
- Hintergrund
- HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.,HLA-DRB3,HLA-DR1B,HLA-DR3B,major histocompatibility complex,class II,DR beta 3,Immunology & Inflammation,HLA-DRB3
- Molekulargewicht
- 29 kDa
- Gen-ID
- 3125
- UniProt
- P79483
- Pathways
- T-Zell Rezeptor Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
-