Gelsolin Antikörper
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- Target Alle Gelsolin (GSN) Antikörper anzeigen
- Gelsolin (GSN)
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Gelsolin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant human full-length protein
- Klon
- CPTC-Gelsolin-1
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product GSN Primärantikörper
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- Applikationshinweise
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Positive Control: MCF cell lysate, Tonsil.
Known Application: Western Blot (0.5-1.0 μg/mL), Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- Gelsolin (GSN)
- Andere Bezeichnung
- GSN (GSN Produkte)
- Synonyme
- ADF antikoerper, AGEL antikoerper, CG1106 antikoerper, DGS antikoerper, Dmel\\CG1106 antikoerper, gel antikoerper, scin antikoerper, cb107 antikoerper, gsn antikoerper, sb:cb107 antikoerper, u-gelsolin antikoerper, wu:fi16f06 antikoerper, gelsolin antikoerper, Gelsolin antikoerper, gelsolin S homeolog antikoerper, gelsolin a antikoerper, GSN antikoerper, Gel antikoerper, Gsn antikoerper, gsn.S antikoerper, gsn antikoerper, gsna antikoerper
- Hintergrund
- Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
- Molekulargewicht
- 90kDa
- Gen-ID
- 2934
- UniProt
- P06396
- Pathways
- Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie
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