FCGR3A Antikörper

Produktnummer ABIN6939379

Produktdetails anti-FCGR3A Antikörper

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR3A Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Spezifität: It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Aufreinigung: Purified by Protein A/G

Immunogen: Human CD16 protein

Klon: ICO-116

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: K-562 or U-937 cells. Lymph nodes and tonsils.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FCGR3A

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Andere Bezeichnung: FCGR3A (FCGR3A Produkte)

Synonyme: CD16 antikoerper, CD16A antikoerper, FCG3 antikoerper, FCGR3 antikoerper, FCGRIII antikoerper, FCR-10 antikoerper, FCRIII antikoerper, FCRIIIA antikoerper, IGFR3 antikoerper, Fcgr4 antikoerper, Fc fragment of IgG receptor IIIa antikoerper, FCGR3A antikoerper, Fcgr3a antikoerper

Molekulargewicht: 50-80kDa

Gen-ID: 2214

UniProt: P08637