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FCGR3A Produkte

(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Kategorien

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Ausgewählte FCGR3A Kategorien

FCGR3A Antikörper

High quality antibodies with extensive validation data.

FCGR3A ELISA Kits

Reliable ELISA kits for a wide range of species.

FCGR3A Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene FCGR3A Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7158547
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN6261703
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (3)
Kat. Nr. ABIN515572
Menge 100 μg
Datenblatt Datenblatt

Empfohlene FCGR3A ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (2)
  • (1)
Kat. Nr. ABIN6955740
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6730644
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6951584
Menge 96 tests
Datenblatt Datenblatt

Empfohlene FCGR3A Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (4)
Kat. Nr. ABIN7274281
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (4)
Kat. Nr. ABIN7274282
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (2)
  • (2)
Kat. Nr. ABIN2181078
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren FCGR3A Produkten

de Taeye, Bentlage, Mebius, Meesters, Lissenberg-Thunnissen, Falck, Sénard, Salehi, Wuhrer, Schuurman, Labrijn, Rispens, Vidarsson: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).

Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).

Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).

Zhao, Li, Wu, Li, Liu, Wang, Liu, Li, Wang: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).

Huang, Li, Liu, Ye, Fan, Yuan, Wu, Chen, Jin, Shen, Feng, Zhang: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).

Dakshinamurthy, Mukunda, Prasad Kodaganti, Shenoy, Natarajan, Maliwalave, Halan, Murugesan, Maity: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).

Matt, Lindqvist, Kleinau: "Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered Fc?R Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137474, (2015) (PubMed).

Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).

Kudo, Imai, Lorenzini, Kamiya, Kono, Davidoff, Chng, Campana: "T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing." in: Cancer research, Vol. 74, Issue 1, pp. 93-103, (2014) (PubMed).

Tada, Ishii-Watabe, Suzuki, Kawasaki: "Development of a cell-based assay measuring the activation of FcγRIIa for the characterization of therapeutic monoclonal antibodies." in: PLoS ONE, Vol. 9, Issue 4, pp. e95787, (2014) (PubMed).

Synonyme und alternative Namen zu FCGR3A

Fc fragment of IgG receptor IIIa (FCGR3A), Fc fragment of IgG receptor IIIa (Fcgr3a), CD16, CD16A, FCG3, FCGR3, Fcgr4, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3

Bezeichner auf Proteinebene für FCGR3A

  • CD16a antigen
  • Fc fragment of IgG, low affinity III, receptor for (CD16)
  • Fc gamma receptor III-A
  • Fc-gamma RIII-alpha
  • Fc-gamma RIIIa
  • Fc-gamma receptor III-2 (CD 16)
  • Fc-gamma receptor IIIb (CD16)
  • FcgammaRIIIA
  • fc-gamma RIII
  • igG Fc receptor III-2
  • immunoglobulin G Fc receptor III
  • low affinity immunoglobulin gamma Fc region receptor III-A
  • neutrophil-specific antigen NA
  • Fc fragment of IgG intermediate affinity IV receptor
  • Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  • transmembrane receptor FcgammaRIII-X
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