Rekombinanter PTGS2 Antikörper (AA 442-572)
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- Target Alle PTGS2 Antikörper anzeigen
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- AA 442-572
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser PTGS2 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90 % of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
- Klon
- COX2-3232R
- Isotyp
- IgG
- Top Product
- Discover our top product PTGS2 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human colon or lung carcinoma tissue (IHC).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
- Andere Bezeichnung
- PTGS2 (PTGS2 Produkte)
- Synonyme
- COX-2 antikoerper, COX2 antikoerper, GRIPGHS antikoerper, PGG/HS antikoerper, PGHS-2 antikoerper, PHS-2 antikoerper, hCox-2 antikoerper, Cox-2 antikoerper, Pghs2 antikoerper, TIS10 antikoerper, Cox2 antikoerper, cox-2 antikoerper, CEF147 antikoerper, PGHS2 antikoerper, PHSII antikoerper, cox2 antikoerper, gripghs antikoerper, pgg/hs antikoerper, pghs-2 antikoerper, phs-2 antikoerper, PTGS2 antikoerper, hcox-2 antikoerper, fj02a10 antikoerper, ptgs2 antikoerper, unp1239 antikoerper, wu:fj02a10 antikoerper, zCOX-2 antikoerper, si:dkey-97o5.6 antikoerper, prostaglandin-endoperoxide synthase 2 antikoerper, prostaglandin G/H synthase 2 antikoerper, prostaglandin-endoperoxide synthase 2S homeolog antikoerper, prostaglandin-endoperoxide synthase 2a antikoerper, prostaglandin-endoperoxide synthase 2b antikoerper, PTGS2 antikoerper, Ptgs2 antikoerper, LOC100136456 antikoerper, ptgs2.S antikoerper, ptgs2 antikoerper, ptgs2a antikoerper, ptgs2b antikoerper
- Hintergrund
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Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, GRIPGHS, Macrophage activation-associated marker protein P71/73, PES-2, PGG/HS, PGHS-2, Prostaglandin endoperoxide synthase 2, Prostaglandin endoperoxide synthase 2 (PTGS2), TIS10,Cycloxygenase-2 (COX-2)
Cellular localisation: Cytoplasmic - Molekulargewicht
- 70-72kDa
- Gen-ID
- 5743, 196384
- UniProt
- P35354
- Pathways
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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