HLA-DRB3 Antikörper

Produktnummer ABIN6937422

Produktdetails anti-HLA-DRB3 Antikörper

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-DRB3 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Spezifität: This MAb reacts with the HLA-DRB3 antigen, a member of MHC class II molecules.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

Kreuzreaktivität (Details): Human. Baboon. Chimpanzee. Monkey. Squirrel. Dog.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human REH cells (non-T, non-B leukemia cell line)

Klon: Bra30

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu HLA-DRB3

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Andere Bezeichnung: HLA-DRB3 (HLA-DRB3 Produkte)

Synonyme: HLA-DR3B antikoerper, BLA-DRB3 antikoerper, Bota-DRB01 antikoerper, Bota-DRB02 antikoerper, Bota-DRB04 antikoerper, Bota-DRB07 antikoerper, Bota-DRB21 antikoerper, Bota-DRB22 antikoerper, LA-DRB antikoerper, major histocompatibility complex, class II, DR beta 3 antikoerper, major histocompatibility complex, class II, DRB3 antikoerper, HLA-DRB3 antikoerper, BOLA-DRB3 antikoerper

Hintergrund: HLA class II histocompatibility antigen DR beta 3 chain, HLADR3B, Major histocompatibility complex, class II DR beta 3,HLA-DRB (MHC II)
Cellular localisation: Cell Surface

Molekulargewicht: ~28kDa (beta chain)

Gen-ID: 3123, 534322

UniProt: P01911

Pathways: T-Zell Rezeptor Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints