Interferon Regulatory Factor 3 (IRF3) (AA 60-95) Antikörper

Details zu Produkt Nr. ABIN682588, Anbieter: Anmelden zum Anzeigen
Antigen
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Epitop
AA 60-95
27
21
19
19
18
17
15
14
12
11
9
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
289
121
70
7
6
6
3
2
2
1
1
1
1
Wirt
Kaninchen
256
63
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
266
129
103
77
49
41
28
25
25
14
14
8
4
3
3
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide derived from human IRF3
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Irf3 (IRF3 Antibody Abstract)
Hintergrund

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

Gen-ID 3661
UniProt Q14653
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 60-95) antibody (ABIN682588) Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-IRF3 Polyclonal ...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 60-95) antibody (ABIN682588) Formalin-fixed and paraffin embedded human kidney labeled with Anti-IRF3 Polyclonal A...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 60-95) antibody (ABIN682588) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-IRF3 Pol...
Produkt verwendet in: Fan, Li, Zhu, Sui, Chen, Deng, Sui, Wang: "NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows." in: Biotechnology letters, Vol. 38, Issue 11, pp. 1839-1849, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Cow (Bovine)).

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