TCF7L2 Antikörper (AA 401-550) (HRP)
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- Target Alle TCF7L2 Antikörper anzeigen
- TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
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Bindungsspezifität
- AA 401-550
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TCF7L2 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Pig,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TCF7L2
- Isotyp
- IgG
- Top Product
- Discover our top product TCF7L2 Primärantikörper
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- Applikationshinweise
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IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
- Andere Bezeichnung
- TCF7L2 (TCF7L2 Produkte)
- Synonyme
- TCF4B antikoerper, TCF4E antikoerper, Tcf-4 antikoerper, Tcf4 antikoerper, mTcf-4B antikoerper, mTcf-4E antikoerper, tcf4 antikoerper, XTCF-4 antikoerper, tcf4e antikoerper, TCF4 antikoerper, TCF-4 antikoerper, TCFL2 antikoerper, transcription factor 7 like 2 antikoerper, transcription factor 7-like 2 antikoerper, transcription factor 7 like 2, T cell specific, HMG box antikoerper, transcription factor 7 like 2 L homeolog antikoerper, transcription factor 7-like 2 (T-cell specific, HMG-box) antikoerper, TCF7L2 antikoerper, LOC100545943 antikoerper, Tcf7l2 antikoerper, tcf7l2 antikoerper, tcf7l2.L antikoerper
- Hintergrund
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Synonyms: TCF4, TCF-4, Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, hTCF-4, TCF7L2
Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
- Gen-ID
- 6934
- UniProt
- Q9NQB0
- Pathways
- WNT Signalweg, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
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