MMP2 Antikörper (Matrix Metalloproteinase 2) (AA 20-70)

Details for Product anti-MMP2 Antibody No. ABIN668286, Anbieter: Anmelden zum Anzeigen
Antigen
  • 2-MMP
  • CG1794
  • DM2-MMP
  • Dm2-MMP
  • Dmel\\CG1794
  • MMP2
  • anon-WO0118547.84
  • dm-2MMP
  • dmmp2
  • l(2)02353
  • mmp2
  • wu:fa99h12
  • wu:fk89d01
  • fgmmp-2
  • Mmp-2
  • LOC100135793
  • Clg4a
  • GelA
  • MMP-2
  • CLG4
  • CLG4A
  • MMP-II
  • MONA
  • TBE-1
  • matrix metallopeptidase 2
  • Matrix metalloproteinase 2
  • matrix metalloproteinase 2
  • matrix metalloproteinase-2
  • MMP2
  • Mmp2
  • mmp2
  • LOC657982
  • LOC100135793
Epitop
AA 20-70
20
19
16
15
15
15
12
11
9
8
8
8
6
6
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
382
170
162
32
18
15
12
11
5
5
5
4
4
2
2
2
2
2
1
1
1
Wirt
Kaninchen
222
175
3
2
1
Klonalität
Polyklonal
Konjugat
Dieser MMP2 Antikörper ist unkonjugiert
17
15
13
9
9
7
6
6
5
5
5
5
4
4
4
4
4
4
4
3
3
3
3
3
3
3
2
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
303
162
95
94
87
80
69
47
42
38
6
5
3
3
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen MAT conjugated synthetic peptide derived from human MMP2
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung MMP2 (MMP2 Antibody Abstract)
Hintergrund

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Subcellular location: Secreted

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

Gen-ID 4313
UniProt P08253
Pathways Activation of Innate immune Response
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-MMP-2 Polyclo...
Immunohistochemistry (IHC) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (Image 2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded Mouse lung, Antigen retrieval by boiling in...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Formalin-fixed and paraffin embedded rat carotid artery Anti-MMP-2 Polyclonal Antibod...
 image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) HT1080 lysates probed with MMP-2 Polyclonal Antibody, Unconjugated at 1:300 dilution...
 image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) HeLa cells probed with MMP2 Polyclonal Antibody, unconjugated at 1:100 dilution for ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded Rat Brain Antigen retrieval by boiling in s...
Produkt verwendet in: Gao, Li, Liu, Wang, Zhang, Li, Bu: "Effect of Telmisartan on Preventing Learning and Memory Deficits Via Peroxisome Proliferator-Activated Receptor-γ in Vascular Dementia Spontaneously Hypertensive Rats." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 27, Issue 2, pp. 277-285, 2018 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: brain

Wang, Chen, Ke, Li: "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." in: Peptides, Vol. 90, pp. 17-26, 2017 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rabbit). Weitere Details: Sample: abdominal aorta

Varghese, Joseph, S R, B S, Sreelekha: "The inhibitory effect of anti- tumor polysaccharide from Punica granatum on metastasis." in: International journal of biological macromolecules, Vol. 103, pp. 1000-1010, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Vendrov, Stevenson, Alahari, Pan, Wickline, Madamanchi, Runge: "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." in: Journal of the American Heart Association, Vol. 6, Issue 11, 2017 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Frozen Sections) (IHC (fro)) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: heart

Ni, Ding, Zhou, Qiu, Tang: "Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats." in: European journal of pharmacology, Vol. 764, pp. 448-456, 2015 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Kidney

Madka, Mohammed, Li, Zhang, Kumar, Lightfoot, Wu, Steele, Kopelovich, Rao: "TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma." in: American journal of cancer research, Vol. 5, Issue 10, pp. 3030-41, 2015 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: bladder tumor

Zhu, Chen, Chen, Chen, Song, Sun, Zhao: "Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients." in: PLoS ONE, Vol. 9, Issue 7, pp. e103882, 2014 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Human).

Zhang, Qi, Cao, Zu, Chen, Li, Qi: "5-Aza-2'-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line." in: Cancer biotherapy & radiopharmaceuticals, 2013 (PubMed).

Qin, Fan, Zhao, Cui, Wei, Kohama, Gordon, Li, Gao: "Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor." in: IUBMB life, Vol. 65, Issue 1, pp. 67-75, 2013 (PubMed). (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: heart

Fang, Wu, Huang: "Raloxifene upregulated mesangial cell MMP-2 activity via ER-? through transcriptional regulation." in: Cell biochemistry and biophysics, Vol. 67, Issue 2, pp. 607-13, 2013 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Wu, Ning, Zeng, Fan, Zhou, Zhang, Zhang, Chen, Gao, Wang, Guo, Li, Wang, He: "Silibinin inhibits ?-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness." in: Cellular signalling, Vol. 25, Issue 12, pp. 2625-33, 2013 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: "PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription." in: Cellular signalling, Vol. 24, Issue 12, pp. 2273-82, 2012 (PubMed). (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: xenograft tissues

Wu, Zeng, Zhou, Fan, Chen, Wang, Zhang, Wang, He: "Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development." in: Urologic oncology, 2012 (PubMed).

Wu, Zeng, Li, Fan, Zhang, Xue, Zhu, Yang, Wang, He: "Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors." in: Oncology reports, Vol. 23, Issue 6, pp. 1545-52, 2010 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

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