SIRPA Antikörper

Produktnummer ABIN5965376

Produktdetails anti-SIRPA Antikörper

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SIRPA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: SIRPA (SIRPA Produkte)

Synonyme: BIT antikoerper, CD172A antikoerper, MFR antikoerper, MYD-1 antikoerper, P84 antikoerper, PTPNS1 antikoerper, SHPS1 antikoerper, SIRP antikoerper, SIRPA antikoerper, SIRP-A1 antikoerper, SIRP-B1 antikoerper, AI835480 antikoerper, Bit antikoerper, CD172a antikoerper, Ptpns1 antikoerper, SHP-1 antikoerper, SHPS-1 antikoerper, swc3 antikoerper, signal regulatory protein alpha antikoerper, myeloperoxidase antikoerper, signal-regulatory protein alpha antikoerper, tyrosine-protein phosphatase non-receptor type substrate 1 antikoerper, SIRPA antikoerper, MPO antikoerper, LOC458039 antikoerper, LOC100400378 antikoerper, LOC100590224 antikoerper, Sirpa antikoerper

Hintergrund:

Synonyms: Signal regulatory protein alpha type 1,Bit,Brain Ig like molecule with tyrosine based activation motifs,Brain Ig-like molecule with tyrosine-based activation motifs,Brain immunoglobulin like molecule with tyrosine based activation motifs,CD172 antigen like family member A,CD172 antigen-like family member A,CD172a,CD172a antigen,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MFR,MYD 1,Myd 1 antigen,MyD-1 antigen,p84,Protein tyrosine phosphatase non receptor type substrate 1,PTPNS1,SHP substrate 1,SHPS-1,SHPS1,SHPS1,Signal regulatory protein alpha 2,Signal regulatory protein alpha 3,Signal regulatory protein alpha,Signal regulatory protein alpha type 2,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,Signal-regulatory protein alpha-3,SIRP,Sirp-alpha-1,Sirp-alpha-2,Sirp-alpha-3,SIRPA,SIRPalpha,SIRPalpha1,SIRPalpha2,SIRPalpha3,Tyrosine phosphatase SHP substrate 1,Tyrosine protein phosphatase non receptor type substrate 1,Tyrosine-protein phosphatase non-receptor type substrate 1

Background: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Molekulargewicht:

Observed_MW: 120kDa

Calculated_MW: 54kDa/55kDa

Gen-ID: 140885

UniProt: P78324