SIRPA Antikörper (AA 235-373)

Produktnummer ABIN5611267

Produktdetails anti-SIRPA Antikörper

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Bindungsspezifität: AA 235-373

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIRPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Neutralization (Neut)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human CD172A (AA: extra 235-373) expressed in E. coli.

Klon: 2H7E2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-SIRPA Antikörper (ABIN5611267)

Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." in: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: CD172A (SIRPA Produkte)

Synonyme: BIT antikoerper, CD172A antikoerper, MFR antikoerper, MYD-1 antikoerper, P84 antikoerper, PTPNS1 antikoerper, SHPS1 antikoerper, SIRP antikoerper, SIRPA antikoerper, SIRP-A1 antikoerper, SIRP-B1 antikoerper, AI835480 antikoerper, Bit antikoerper, CD172a antikoerper, Ptpns1 antikoerper, SHP-1 antikoerper, SHPS-1 antikoerper, swc3 antikoerper, signal regulatory protein alpha antikoerper, myeloperoxidase antikoerper, signal-regulatory protein alpha antikoerper, tyrosine-protein phosphatase non-receptor type substrate 1 antikoerper, SIRPA antikoerper, MPO antikoerper, LOC458039 antikoerper, LOC100400378 antikoerper, LOC100590224 antikoerper, Sirpa antikoerper

Hintergrund:

Description: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Aliases: BIT, MFR, P84, SIRP, MYD-1, SHPS1, SIRPA, PTPNS1

Molekulargewicht: 55 kDa

Gen-ID: 140885

HGNC: 140885