Ghrelin Antikörper

Produktnummer ABIN6292644

Produktdetails anti-Ghrelin Antikörper

Target: Ghrelin (GHRL)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ghrelin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human GHRL

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Kommentare:

Highest level in stomach, All forms are found in serum as well, Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu Ghrelin

Target: Ghrelin (GHRL)

Andere Bezeichnung: GHRL (GHRL Produkte)

Synonyme: 2210006E23Rik antikoerper, Ghr antikoerper, MTLRP antikoerper, MTLRPAP antikoerper, m46 antikoerper, Gh1-1 antikoerper, GRHL antikoerper, MTLRP-AP antikoerper, GHR antikoerper, ghrelin antikoerper, ghrelin and obestatin prepropeptide antikoerper, ghrelin/obestatin prepropeptide antikoerper, Ghrl antikoerper, GHRL antikoerper, ghrl antikoerper

Hintergrund: This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

Molekulargewicht: 12.911 kDa

Gen-ID: 51738

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour