CXCR7 Antikörper

Produktnummer ABIN6291935

Produktdetails anti-CXCR7 Antikörper

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human ACKR3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells, Lower expression detected in CD4+ T-lymphocytes and natural killer cells, In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus, Expressed in tubular formation in the kidney, Highly expressed in astroglial tumor endothelial, microglial and glioma cells, Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines, Expressed in breast carcinomas but not in normal breast tissue (at protein level)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu CXCR7

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Andere Bezeichnung: ACKR3 (CXCR7 Produkte)

Synonyme: CMKOR1 antikoerper, CXC-R7 antikoerper, CXCR-7 antikoerper, CXCR7 antikoerper, GPR159 antikoerper, RDC-1 antikoerper, RDC1 antikoerper, AW541270 antikoerper, Cmkor1 antikoerper, Cxcr7 antikoerper, Rdc1 antikoerper, ackr3 antikoerper, cxcr7 antikoerper, rdc1 antikoerper, xcxcr7 antikoerper, atypical chemokine receptor 3 antikoerper, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antikoerper, atypical chemokine receptor 3 L homeolog antikoerper, ACKR3 antikoerper, MmrVgp88 antikoerper, Ackr3 antikoerper, ackr3.L antikoerper

Hintergrund: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.

Molekulargewicht: 41.493 kDa

Gen-ID: 57007

UniProt: P25106

Pathways: Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling