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CXCR7 Antikörper (Internal Region)

CXCR7 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258040
  • Target Alle CXCR7 Antikörper anzeigen
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Bindungsspezifität
    • 20
    • 14
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 104
    • 46
    • 43
    • 8
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 86
    • 17
    • 1
    Kaninchen
    Klonalität
    • 76
    • 27
    • 1
    Polyklonal
    Konjugat
    • 42
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CXCR7 Antikörper ist unkonjugiert
    Applikation
    • 74
    • 40
    • 35
    • 19
    • 16
    • 16
    • 13
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    CXCR7 Antibody detects endogenous levels of total CXCR7.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CXCR7, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CXCR7 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Andere Bezeichnung
    ACKR3 (CXCR7 Produkte)
    Synonyme
    CMKOR1 antikoerper, CXC-R7 antikoerper, CXCR-7 antikoerper, CXCR7 antikoerper, GPR159 antikoerper, RDC-1 antikoerper, RDC1 antikoerper, AW541270 antikoerper, Cmkor1 antikoerper, Cxcr7 antikoerper, Rdc1 antikoerper, ackr3 antikoerper, cxcr7 antikoerper, rdc1 antikoerper, xcxcr7 antikoerper, atypical chemokine receptor 3 antikoerper, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antikoerper, atypical chemokine receptor 3 L homeolog antikoerper, ACKR3 antikoerper, MmrVgp88 antikoerper, Ackr3 antikoerper, ackr3.L antikoerper
    Hintergrund

    Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

    Gene: ACKR3

    Molekulargewicht
    41 kDa
    Gen-ID
    57007
    UniProt
    P25106
    Pathways
    Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
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