PRKAR2B Antikörper
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- Target Alle PRKAR2B Antikörper anzeigen
- PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PRKAR2B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein of human PRKAR2B
- Isotyp
- IgG
- Top Product
- Discover our top product PRKAR2B Primärantikörper
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- Applikationshinweise
- WB 1:500 - 1:2000
- Kommentare
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Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta, Their expression varies among tissues and is in some cases constitutive and in others inducible
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
- Andere Bezeichnung
- PRKAR2B (PRKAR2B Produkte)
- Synonyme
- MGC83177 antikoerper, PRKAR2B antikoerper, AI451071 antikoerper, AW061005 antikoerper, PKARIIbeta antikoerper, Pkarb2 antikoerper, RII(beta) antikoerper, RATDNA antikoerper, PRKAR2 antikoerper, RII-BETA antikoerper, protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog antikoerper, protein kinase cAMP-dependent type II regulatory subunit beta antikoerper, protein kinase, cAMP-dependent, regulatory, type II, beta antikoerper, protein kinase, cAMP dependent regulatory, type II beta antikoerper, protein kinase cAMP-dependent type 2 regulatory subunit beta antikoerper, prkar2b.S antikoerper, PRKAR2B antikoerper, prkar2b antikoerper, Prkar2b antikoerper
- Hintergrund
- CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
- Molekulargewicht
- 46.302 kDa
- Gen-ID
- 5577
- UniProt
- P31323
- Pathways
- Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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