ErbB2/Her2 Antikörper (N-Term)

Produktnummer ABIN6287432

Produktdetails anti-ErbB2/Her2 Antikörper

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: HER2 is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. HER2 isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the cytoplasm and nucleus. It is involved in RET signalling, the GPCR pathway and signalling by ERBB2. It is a protein tyrosine kinase that is part of several cell surface receptor complexes that need a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex and also regulates outgrowth and stabilization of peripheral microtubules. HER2 is expressed in the cells of the nervous system, liver, intestine, lymph nodes and lung. Mutations in the ERBB2 gene may result in Glioma. STJ96947 was developed from clone 11H9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous ErbB-2/HER-2 proteins.

Spezifität: The antibody detects endogenous ErbB-2/HER-2 proteins.

Produktmerkmale: Mouse monoclonal to HER2.

Aufreinigung: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: Synthetic Peptide

Klon: 11H9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:2000-4000
IHC 1:200

Kommentare:

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: HER2 (ErbB2/Her2 Produkte)

Synonyme: CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper

Gen-ID: 2064

UniProt: P04626

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development