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ErbB2/Her2 Produkte

(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Kategorien

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

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Ausgewählte ErbB2/Her2 Kategorien

ErbB2/Her2 Antikörper

High quality antibodies with extensive validation data.

ErbB2/Her2 ELISA Kits

Reliable ELISA kits for a wide range of species.

ErbB2/Her2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ErbB2/Her2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt

Applikation WB
Validierungen
  • (7)
Kat. Nr. ABIN6254225
Menge 600 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, ICC, IF, IHC, IP, WB
Validierungen
  • (12)
Kat. Nr. ABIN6256054
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, ICC, IF, IHC, WB
Validierungen
  • (12)
Kat. Nr. ABIN6256630
Menge 100 μL
Datenblatt Datenblatt

Empfohlene ErbB2/Her2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (5)
Kat. Nr. ABIN6730948
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6959063
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6973408
Menge 96 tests
Datenblatt Datenblatt

Empfohlene ErbB2/Her2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (5)
Kat. Nr. ABIN7274799
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (15)
  • (3)
Kat. Nr. ABIN2181214
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (4)
Kat. Nr. ABIN7274800
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren ErbB2/Her2 Produkten

Maisel, Broka, Atwell, Bunch, Kupp, Singh, Mehta, Schroeder: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).

Farràs, Román, Camps, Miret, Martínez, Pujol, Casablancas, Cairó: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).

Murakami, Matsumoto, Kanamori: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).

Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

Helsen, Hammill, Lau, Mwawasi, Afsahi, Bezverbnaya, Newhook, Hayes, Aarts, Bojovic, Denisova, Kwiecien, Brain, Derocher, Milne, Nelson, Bramson: "The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity." in: Nature communications, Vol. 9, Issue 1, pp. 3049, (2019) (PubMed).

Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

Synonyme und alternative Namen zu ErbB2/Her2

erb-b2 receptor tyrosine kinase 2 (ERBB2), erb-b2 receptor tyrosine kinase 2 (Erbb2), erb-b2 receptor tyrosine kinase 2 (erbb2), c-erbB2, c-neu, CD340, erb2, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, NEU, Neu, NGL, TKR1, wu:fv70f10, zgc:63601

Bezeichner auf Proteinebene für ErbB2/Her2

  • c-erb B2/neu protein
  • herstatin
  • metastatic lymph node gene 19 protein
  • neuro/glioblastoma derived oncogene homolog
  • neuroblastoma/glioblastoma derived oncogene homolog
  • p185erbB2
  • proto-oncogene Neu
  • proto-oncogene c-ErbB-2
  • receptor tyrosine-protein kinase erbB-2
  • tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • Neu oncogene
  • avian erythroblastosis oncogene B 2
  • c-erbB-2
  • proto-oncogene NEU
  • erbB-2
  • Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
  • C-erbB-2
  • NEU proto-oncogene
  • epidermal growth factor receptor-related protein
  • p185neu
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • epidermal growth factor receptor type 2
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