ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper
(ErbB2/Her2 (Trastuzumab Biosimilar))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
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Empfohlene ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
FACS, ELISA, IHC
Validierungen
- (1)
Kat. Nr.
ABIN5668227
Menge
200 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
FACS, ELISA, IHC
Validierungen
- (1)
Kat. Nr.
ABIN5668226
Menge
200 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
FACS, in vivo
Validierungen
Kat. Nr.
ABIN7200659
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ErbB2/Her2 (Trastuzumab Biosimilar) Produkten
: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).Synonyme und alternative Namen zu ErbB2/Her2 (Trastuzumab Biosimilar)
erb-b2 receptor tyrosine kinase 2 (ERBB2), CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1Bezeichner auf Proteinebene für ErbB2/Her2 (Trastuzumab Biosimilar)
- c-erb B2/neu protein
- herstatin
- metastatic lymph node gene 19 protein
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- p185erbB2
- proto-oncogene Neu
- proto-oncogene c-ErbB-2
- receptor tyrosine-protein kinase erbB-2
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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