BCL6 Antikörper (Internal Region)

Produktnummer ABIN6282755

Produktdetails anti-BCL6 Antikörper

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Bindungsspezifität: AA 271-320, Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Bcl-6 is a protein encoded by the BCL6 gene which is approximately 78,8 kDa. Bcl-6 is localised to the nucleus. It is involved in cytokine signalling in immune system, gene expression and FoxO signalling pathway. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. It is mainly required for germinal centre formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. It forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Bcl-6 is expressed in germinal centre T- and B-cells and in primary immature dendritic cells. Mutations in the BCL6 gene may result in b-cell lymphomas. STJ96676 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bcl-6 protein.

Spezifität: Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

Produktmerkmale: Rabbit polyclonal to Bcl-6.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Bcl-6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000

Kommentare:

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: Bcl-6 (BCL6 Produkte)

Synonyme: bcl5 antikoerper, laz3 antikoerper, bcl6a antikoerper, znf51 antikoerper, zbtb27 antikoerper, MGC132260 antikoerper, Bcl5 antikoerper, BCL5 antikoerper, BCL6A antikoerper, LAZ3 antikoerper, ZBTB27 antikoerper, ZNF51 antikoerper, B-cell CLL/lymphoma 6 L homeolog antikoerper, B-cell CLL/lymphoma 6 antikoerper, B cell leukemia/lymphoma 6 antikoerper, bcl6.L antikoerper, bcl6 antikoerper, BCL6 antikoerper, Bcl6 antikoerper

Molekulargewicht: 78 kDa

Gen-ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus