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BCL6 Antikörper (AA 256-389)

BCL6 Reaktivität: Human IHC, StM Wirt: Maus Monoclonal BCL6-1527 unconjugated
Produktnummer ABIN6940529
  • Target Alle BCL6 Antikörper anzeigen
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Bindungsspezifität
    • 27
    • 22
    • 15
    • 11
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 256-389
    Reaktivität
    • 144
    • 76
    • 26
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 90
    • 52
    • 2
    • 1
    Maus
    Klonalität
    • 79
    • 66
    Monoklonal
    Konjugat
    • 68
    • 13
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BCL6 Antikörper ist unkonjugiert
    Applikation
    • 91
    • 46
    • 36
    • 33
    • 33
    • 18
    • 17
    • 13
    • 13
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large () cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
    Klon
    BCL6-1527
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product BCL6 Primärantikörper
  • Applikationshinweise

    Positive Control: Raji or Ramos cells. Tonsil or Hodgkin's lymphoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Andere Bezeichnung
    BCL6 (BCL6 Produkte)
    Synonyme
    bcl5 antikoerper, laz3 antikoerper, bcl6a antikoerper, znf51 antikoerper, zbtb27 antikoerper, MGC132260 antikoerper, Bcl5 antikoerper, BCL5 antikoerper, BCL6A antikoerper, LAZ3 antikoerper, ZBTB27 antikoerper, ZNF51 antikoerper, B-cell CLL/lymphoma 6 L homeolog antikoerper, B-cell CLL/lymphoma 6 antikoerper, B cell leukemia/lymphoma 6 antikoerper, bcl6.L antikoerper, bcl6 antikoerper, BCL6 antikoerper, Bcl6 antikoerper
    Molekulargewicht
    95kDa
    Gen-ID
    604
    UniProt
    P41182
    Pathways
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
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