SIGMAR1 Antikörper (Internal Region)

Produktnummer ABIN6265082

Produktdetails anti-SIGMAR1 Antikörper

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGMAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: SIGMAR1 Antibody detects endogenous levels of total SIGMAR1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SIGMAR1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:50-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Andere Bezeichnung: SIGMAR1 (SIGMAR1 Produkte)

Synonyme: ALS16 antikoerper, OPRS1 antikoerper, SIG-1R antikoerper, SR-BP antikoerper, SR-BP1 antikoerper, SRBP antikoerper, sigma1R antikoerper, AL024364 antikoerper, Oprs1 antikoerper, mSigmaR1 antikoerper, Sigma1R antikoerper, oprs1 antikoerper, zgc:56378 antikoerper, sigma non-opioid intracellular receptor 1 antikoerper, sigma non-opioid intracellular receptor 1 L homeolog antikoerper, SIGMAR1 antikoerper, Sigmar1 antikoerper, sigmar1.L antikoerper, sigmar1 antikoerper

Hintergrund:

Description: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).

Gene: SIGMAR1

Molekulargewicht: 25kDa

Gen-ID: 10280

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interaktom