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P4HB Antikörper (C-Term)

P4HB Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6276401
  • Target Alle P4HB Antikörper anzeigen
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Bindungsspezifität
    • 21
    • 19
    • 15
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 106
    • 75
    • 66
    • 23
    • 22
    • 22
    • 20
    • 18
    • 18
    • 16
    • 10
    • 10
    • 8
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 116
    • 27
    • 2
    Kaninchen
    Klonalität
    • 109
    • 36
    Polyklonal
    Konjugat
    • 61
    • 16
    • 15
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser P4HB Antikörper ist unkonjugiert
    Applikation
    • 111
    • 67
    • 44
    • 44
    • 43
    • 36
    • 17
    • 15
    • 14
    • 13
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    P4HB Antibody detects endogenous levels of total P4HB.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human P4HB, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product P4HB Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Andere Bezeichnung
    P4HB (P4HB Produkte)
    Synonyme
    DSI antikoerper, ERBA2L antikoerper, GIT antikoerper, P4Hbeta antikoerper, PDI antikoerper, PDIA1 antikoerper, PHDB antikoerper, PO4DB antikoerper, PO4HB antikoerper, PROHB antikoerper, PDA2 antikoerper, PDIP antikoerper, PDIR antikoerper, ERp59 antikoerper, Pdia1 antikoerper, Thbp antikoerper, p55 antikoerper, XPDIp antikoerper, pdi antikoerper, 1810041F13Rik antikoerper, AI661267 antikoerper, Pdip antikoerper, Pdipl antikoerper, p58 antikoerper, prolyl 4-hydroxylase subunit beta antikoerper, protein disulfide isomerase family A member 2 antikoerper, prolyl 4-hydroxylase, beta polypeptide antikoerper, protein disulfide isomerase family A member 2 L homeolog antikoerper, protein disulfide isomerase associated 2 antikoerper, prolyl 4-hydroxylase subunit beta L homeolog antikoerper, protein disulfide-isomerase antikoerper, P4HB antikoerper, PDIA2 antikoerper, P4hb antikoerper, pdia2.L antikoerper, Pdia2 antikoerper, p4hb.L antikoerper, LOC8281065 antikoerper
    Hintergrund

    Description: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9, the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).

    Gene: P4HB

    Molekulargewicht
    57kDa
    Gen-ID
    5034
    UniProt
    P07237
    Pathways
    Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
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