MCL-1 Antikörper (Internal Region)

Produktnummer ABIN6263156

Produktdetails anti-MCL-1 Antikörper

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCL-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: MCL1 Antibody detects endogenous levels of total MCL1.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MCL1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-MCL-1 Antikörper (ABIN6263156)

Qian, Chen, Meng, Ma, Meng, Wang, Yu, Zask, Shen, Yu: "Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer." in: Oncotarget, Vol. 7, Issue 41, pp. 67071-67086, (2018) (PubMed).

Li, Zhao, Zhang, Lang, Yu: "Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers." in: Acta pharmacologica Sinica, (2018) (PubMed).

Details zu MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Andere Bezeichnung: MCL1 (MCL1 Produkte)

Synonyme: BCL2L3 antikoerper, EAT antikoerper, MCL1-ES antikoerper, MCL1L antikoerper, MCL1S antikoerper, Mcl-1 antikoerper, TM antikoerper, bcl2-L-3 antikoerper, mcl1/EAT antikoerper, AW556805 antikoerper, mcl-1 antikoerper, fb72f02 antikoerper, wu:fb70a08 antikoerper, wu:fb72f02 antikoerper, zfMLP1 antikoerper, zfMcl-1a antikoerper, zgc:109835 antikoerper, zgc:109763 antikoerper, E3 antikoerper, E3-2 antikoerper, RNE3 antikoerper, RNU107 antikoerper, SNORA63A antikoerper, elF-4AII antikoerper, MCL1, BCL2 family apoptosis regulator antikoerper, myeloid cell leukemia sequence 1 antikoerper, MCL1, BCL2 family apoptosis regulator a antikoerper, MCL1, BCL2 family apoptosis regulator b antikoerper, small nucleolar RNA, H/ACA box 63 antikoerper, MCL1 antikoerper, Mcl1 antikoerper, mcl1a antikoerper, mcl1b antikoerper, SNORA63 antikoerper

Hintergrund:

Description: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Gene: MCL1

Molekulargewicht: 37 kDa

Gen-ID: 4170

UniProt: Q07820

Pathways: MAPK Signalweg