MAPK7 Antikörper (Internal Region)

Produktnummer ABIN6263117

Produktdetails anti-MAPK7 Antikörper

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: ERK5 Antibody detects endogenous levels of total ERK5.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ERK5, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Andere Bezeichnung: MAPK7 (MAPK7 Produkte)

Synonyme: BMK1 antikoerper, ERK4 antikoerper, ERK5 antikoerper, PRKM7 antikoerper, Erk5-T antikoerper, ATMPK7 antikoerper, F8D23.5 antikoerper, F8D23_5 antikoerper, MAP kinase 7 antikoerper, Bmk1 antikoerper, Erk5 antikoerper, Prkm7 antikoerper, ERK-5 antikoerper, bmk1 antikoerper, erk4 antikoerper, mapk7 antikoerper, prkm7 antikoerper, mitogen-activated protein kinase 7 antikoerper, MAP kinase 7 antikoerper, mitogen-activated protein kinase 7 L homeolog antikoerper, MAPK7 antikoerper, Mapk7 antikoerper, MPK7 antikoerper, mapk7.L antikoerper

Hintergrund:

Description: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Gene: MAPK7

Molekulargewicht: 89kDa

Gen-ID: 5598

UniProt: Q13164

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling