COPS7B Antikörper (Internal Region)

Produktnummer ABIN6260972

Produktdetails anti-COPS7B Antikörper

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS7B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: COPS7B Antibody detects endogenous levels of total COPS7B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human COPS7B, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu COPS7B

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Andere Bezeichnung: COPS7B (COPS7B Produkte)

Synonyme: MGC114836 antikoerper, D1Wsu66e antikoerper, E130114M23 antikoerper, CSN7B antikoerper, COP9 signalosome subunit 7B antikoerper, COP9 signalosome subunit 7B S homeolog antikoerper, Cops7b antikoerper, COPS7B antikoerper, cops7b.S antikoerper

Hintergrund:

Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene: COPS7B

Molekulargewicht: 30 kDa

Gen-ID: 64708

UniProt: Q9H9Q2

Pathways: Zellzyklus