COPS7B Antikörper (AA 1-157)

Produktnummer ABIN7148503

Produktdetails anti-COPS7B Antikörper

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Bindungsspezifität: AA 1-157

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS7B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu COPS7B

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Andere Bezeichnung: COPS7B (COPS7B Produkte)

Synonyme: MGC114836 antikoerper, D1Wsu66e antikoerper, E130114M23 antikoerper, CSN7B antikoerper, COP9 signalosome subunit 7B antikoerper, COP9 signalosome subunit 7B S homeolog antikoerper, Cops7b antikoerper, COPS7B antikoerper, cops7b.S antikoerper

Hintergrund:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: COP9 Complex Homolog Subunit 7b antibody, COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody, COP9 Signalasome Subunit 7b antibody, COP9 signalosome complex subunit 7b antibody, COPS7B antibody, CSN7B_HUMAN antibody, JAB1 Containing Signalosome Subunit 7b antibody, JAB1-containing signalosome subunit 7b antibody, SGN7b antibody, Signalosome subunit 7b antibody

UniProt: Q9H9Q2

Pathways: Zellzyklus