BBS4 Antikörper (Internal Region)

Produktnummer ABIN6260211

Produktdetails anti-BBS4 Antikörper

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: BBS4 Antibody detects endogenous levels of total BBS4.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BBS4, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BBS4

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Andere Bezeichnung: BBS4 (BBS4 Produkte)

Synonyme: CG13232 antikoerper, Dmel\\CG13232 antikoerper, zgc:152964 antikoerper, AW537059 antikoerper, AW742241 antikoerper, D9Ertd464e antikoerper, Bardet-Biedl syndrome 4 antikoerper, bardet-biedl syndrome 4 antikoerper, Bardet-Biedl syndrome 4 (human) antikoerper, BBS4 antikoerper, bbs4 antikoerper, Bbs4 antikoerper

Hintergrund:

Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

Gene: BBS4

Molekulargewicht: 50-60 kDa

Gen-ID: 585

UniProt: Q96RK4

Pathways: Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location