HUWE1 Antikörper (Internal Region)

Produktnummer ABIN6259492

Produktdetails anti-HUWE1 Antikörper

Target: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HUWE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: HUWE1 Antibody detects endogenous levels of total HUWE1.

Homologie: Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HUWE1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu HUWE1

Target: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Andere Bezeichnung: HUWE1 (HUWE1 Produkte)

Synonyme: ARF-BP1 antikoerper, HECTH9 antikoerper, HSPC272 antikoerper, Ib772 antikoerper, LASU1 antikoerper, MULE antikoerper, URE-B1 antikoerper, UREB1 antikoerper, 5430439H10Rik antikoerper, AU041296 antikoerper, Arf-bp1 antikoerper, C430014N20Rik antikoerper, C80292 antikoerper, Gm1718 antikoerper, Mule antikoerper, Ureb1 antikoerper, HUWE1 antikoerper, si:dkey-242a8.2 antikoerper, Huwe1 antikoerper, mule antikoerper, ib772 antikoerper, lasu1 antikoerper, ureb1 antikoerper, hecth9 antikoerper, arf-bp1 antikoerper, hspc272 antikoerper, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase antikoerper, HECT, UBA and WWE domain containing 1 antikoerper, E3 ubiquitin-protein ligase HUWE1 antikoerper, HUWE1 antikoerper, Huwe1 antikoerper, huwe1 antikoerper, LOC100123214 antikoerper, LOC100380641 antikoerper

Hintergrund:

Description: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.

Gene: HUWE1

Molekulargewicht: 481 kDa

Gen-ID: 10075

UniProt: Q7Z6Z7