HUWE1 Antikörper (AA 3201-3400) (HRP)
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- Target Alle HUWE1 Antikörper anzeigen
- HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
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Bindungsspezifität
- AA 3201-3400
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HUWE1 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ARF6
- Isotyp
- IgG
- Top Product
- Discover our top product HUWE1 Primärantikörper
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- Applikationshinweise
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IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
- Andere Bezeichnung
- ARFBP1 (HUWE1 Produkte)
- Synonyme
- ARF-BP1 antikoerper, HECTH9 antikoerper, HSPC272 antikoerper, Ib772 antikoerper, LASU1 antikoerper, MULE antikoerper, URE-B1 antikoerper, UREB1 antikoerper, 5430439H10Rik antikoerper, AU041296 antikoerper, Arf-bp1 antikoerper, C430014N20Rik antikoerper, C80292 antikoerper, Gm1718 antikoerper, Mule antikoerper, Ureb1 antikoerper, HUWE1 antikoerper, si:dkey-242a8.2 antikoerper, Huwe1 antikoerper, mule antikoerper, ib772 antikoerper, lasu1 antikoerper, ureb1 antikoerper, hecth9 antikoerper, arf-bp1 antikoerper, hspc272 antikoerper, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase antikoerper, HECT, UBA and WWE domain containing 1 antikoerper, E3 ubiquitin-protein ligase HUWE1 antikoerper, HUWE1 antikoerper, Huwe1 antikoerper, huwe1 antikoerper, LOC100123214 antikoerper, LOC100380641 antikoerper
- Hintergrund
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Synonyms: ARF binding protein 1, ARF BP1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, E3 ubiquitin protein ligase HUWE1, E3 ubiquitin-protein ligase HUWE1, HECT, HECT domain protein LASU1, HECT UBA and WWE domain containing protein 1, HectH9, Homologous to E6AP carboxyl terminus homologous protein 9, HUWE, Huwe1, HUWE1_HUMAN, Ib772, KIAA0312, KIAA1578, Large structure of UREB1, LASU1, Mcl 1 ubiquitin ligase E3, Mcl-1 ubiquitin ligase E3, MULE, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE B1, URE-B1, URE-binding protein 1, UREB 1, UREB1.
Background: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
- Gen-ID
- 382
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