TEAD1 Antikörper (Internal Region)
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- Target Alle TEAD1 Antikörper anzeigen
- TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TEAD1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- TEAD1 Antibody detects endogenous levels of total TEAD1.
- Homologie
- Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TEAD1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TEAD1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl,sodium azide and glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))
- Andere Bezeichnung
- TEAD1 (TEAD1 Produkte)
- Synonyme
- tead1 antikoerper, zgc:63696 antikoerper, TEAD1 antikoerper, xtead1 antikoerper, 2610024B07Rik antikoerper, B230114H05Rik antikoerper, Gtrgeo5 antikoerper, TEAD-1 antikoerper, TEF-1 antikoerper, Tcf13 antikoerper, mTEF-1 antikoerper, AA antikoerper, NTEF-1 antikoerper, REF1 antikoerper, TCF-13 antikoerper, TCF13 antikoerper, XNTEF-1 antikoerper, xlNTEF-1 antikoerper, TEA domain family member 1a antikoerper, TEA domain transcription factor 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) antikoerper, TEA domain family member 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog antikoerper, TEA domain family member 1b antikoerper, tead1a antikoerper, TEAD1 antikoerper, tead1 antikoerper, Tead1 antikoerper, tead1.S antikoerper, tead1b antikoerper
- Hintergrund
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Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Gene: TEAD1
- Molekulargewicht
- 48 kDa
- Gen-ID
- 7003
- UniProt
- P28347
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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