BARD1 Antikörper (Internal Region)

Produktnummer ABIN6256958

Produktdetails anti-BARD1 Antikörper

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BARD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: BARD1 Antibody detects endogenous levels of total BARD1.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BARD1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BARD1

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Andere Bezeichnung: BARD1 (BARD1 Produkte)

Synonyme: BARD1 antikoerper, LOC100147913 antikoerper, ENSMUSG00000060893 antikoerper, ENSMUSG00000073653 antikoerper, BRCA1 associated RING domain 1 antikoerper, BARD1 antikoerper, bard1 antikoerper, Bard1 antikoerper

Hintergrund:

Description: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Gene: BARD1

Molekulargewicht: 79 kDa

Gen-ID: 580

UniProt: Q99728

Pathways: DNA Reparatur