BARD1 Produkte
(BRCA1 Associated RING Domain 1 (BARD1))
Kategorien
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008].
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Ausgewählte BARD1 Kategorien
BARD1 Antikörper
High quality antibodies with extensive validation data.
BARD1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BARD1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BARD1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN706496
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IF
Validierungen
- (2)
Kat. Nr.
ABIN560033
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (1)
Kat. Nr.
ABIN7188551
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene BARD1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1124118
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1124119
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1124120
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BARD1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346405
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3089922
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3132003
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BARD1 Produkten
: "FOXK2 transcription factor suppresses ER?-positive breast cancer cell growth through down-regulating the stability of ER? via mechanism involving BRCA1/BARD1." in: Scientific reports, Vol. 5, pp. 8796, (2015) (PubMed).: "The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function." in: Cellular signalling, Vol. 27, Issue 9, pp. 1763-71, (2015) (PubMed).
: "Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer." in: Breast cancer research and treatment, Vol. 145, Issue 2, pp. 317-30, (2014) (PubMed).
: "SUMOylation proteins in breast cancer." in: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).
: "Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. ..." in: Cancer research, Vol. 72, Issue 8, pp. 2068-78, (2012) (PubMed).
: "The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci." in: Traffic (Copenhagen, Denmark), Vol. 13, Issue 6, pp. 800-14, (2012) (PubMed).
: "Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome." in: British journal of cancer, Vol. 107, Issue 4, pp. 675-83, (2012) (PubMed).
: "BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair." in: Journal of cell science, Vol. 125, Issue Pt 15, pp. 3529-34, (2012) (PubMed).
: "HERC2 is an E3 ligase that targets BRCA1 for degradation." in: Cancer research, Vol. 70, Issue 15, pp. 6384-92, (2010) (PubMed).
: "Transcriptional autoregulation by BRCA1." in: Cancer research, Vol. 70, Issue 2, pp. 532-42, (2010) (PubMed).
Synonyme und alternative Namen zu BARD1
BRCA1 associated RING domain 1 (BARD1), BRCA1 associated RING domain 1 (bard1), BRCA1 associated RING domain 1 (Bard1), BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913Bezeichner auf Proteinebene für BARD1
- BRCA1 associated RING domain 1
- BRCA1-associated RING domain protein 1-like
- BRCA1 associated RING domain 1 isoform alfa
- BRCA1 associated RING domain 1 isoform beta
- BRCA1 associated RING domain 1 isoform delta
- BRCA1 associated RING domain 1 isoform epsilon
- BRCA1 associated RING domain 1 isoform eta
- BRCA1 associated RING domain 1 isoform gamma
- BRCA1 associated RING domain 1 isoform phi
- BRCA1-associated RING domain gene 1
- BRCA1-associated RING domain protein 1
- BARD-1
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