Band 3/AE1 Produkte
(Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))
Kategorien
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008].
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Ausgewählte Band 3/AE1 Kategorien
Band 3/AE1 Antikörper
High quality antibodies with extensive validation data.
Band 3/AE1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Band 3/AE1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC (p), ICC, IHC (fro)
Validierungen
- (8)
Kat. Nr.
ABIN7441895
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN7270459
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p), IHC (fro)
Validierungen
- (5)
Kat. Nr.
ABIN3043930
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Band 3/AE1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125166
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1320468
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3132501
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Band 3/AE1 Produkten
: "Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g." in: Anemia, Vol. 2012, pp. 659303, (2012) (PubMed).Synonyme und alternative Namen zu Band 3/AE1
solute carrier family 4 member 1 (Diego blood group) (SLC4A1), solute carrier family 4 (anion exchanger), member 1 (Slc4a1), solute carrier family 4 (anion exchanger), member 1a (Diego blood group) (slc4a1a), Band 3 (LOC100136769), erythrocyte membrane protein band 4.1 like 3 (EPB41L3), solute carrier family 4 member 1 (Diego blood group) L homeolog (slc4a1.L), solute carrier family 4 member 1 (SLC4A1), solute carrier family 4 member 1 (Diego blood group) (slc4a1), solute carrier family 4 member 1 (Slc4a1), AE1, Ae1, ae1, band3, BB3, BND3, bnd3, CD233, cd233, DI, EAT, EMPB3, Empb3, empb3, EPB3, epb3, FR, l11Jus51, LOC100136769, MGC80391, MGC152771, RTA1A, rta1a, si:dz180g5.1, slc4a1, SLC4A1, SW, WD, WD1, wd1, WR, zgc:111889, zgc:152771Bezeichner auf Proteinebene für Band 3/AE1
- Diego blood group
- Froese blood group
- Swann blood group
- Waldner blood group
- Wright blood group
- anion exchange protein 1
- anion exchanger 1
- anion exchanger-1
- band 3 anion transport protein
- erythrocyte membrane protein band 3
- erythroid anion exchange protein
- solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- solute carrier family 4, anion exchanger, number 1
- AE 1
- MEB3
- solute carrier family 4 member 1
- solute carrier family 4, anion exchanger, member 1
- ret
- retsina
- AE1/band 3
- erythroid anion exchanger 1
- Band 3
- band 4.1-like protein 3-like
- solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3)
- band 3 anion transport protein-like
- erythroid-specific band 3 protein
- erythrocyte anion transport protein
- Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
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