Band 3/AE1 Antikörper (AA 1-353)

Produktnummer ABIN7270459

Produktdetails anti-Band 3/AE1 Antikörper

Target: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Bindungsspezifität: AA 1-353

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Band 3/AE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: SLC4A1 Rabbit pAb

Sequenz: MEELQDDYED MMEENLEQEE YEDPDIPESQ MEEPAAHDTE ATATDYHTTS HPGTHKVYVE LQELVMDEKN QELRWMEAAR WVQLEENLGE NGAWGRPHLS HLTFWSLLEL RRVFTKGTVL LDLQETSLAG VANQLLDRFI FEDQIRPQDR EELLRALLLK HSHAGELEAL GGVKPAVLTR SGDPSQPLLP QHSSLETQLF CEQGDGGTEG HSPSGILEKI PPDSEATLVL VGRADFLEQP VLGFVRLQEA AELEAVELPV PIRFLFVLLG PEAPHIDYTQ LGRAAATLMS ERVFRIDAYM AQSRGELLHS LEGFLDCSLV LPPTDAPSEQ ALLSLVPVQR ELLRRRYQSS PAK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human SLC4A1 (NP_000333.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Band 3/AE1

Target: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Andere Bezeichnung: SLC4A1 (SLC4A1 Produkte)

Synonyme: AE1 antikoerper, BND3 antikoerper, CD233 antikoerper, DI antikoerper, EMPB3 antikoerper, EPB3 antikoerper, FR antikoerper, RTA1A antikoerper, SW antikoerper, WD antikoerper, WD1 antikoerper, WR antikoerper, Ae1 antikoerper, Empb3 antikoerper, l11Jus51 antikoerper, ae1 antikoerper, band3 antikoerper, MGC152771 antikoerper, zgc:111889 antikoerper, zgc:152771 antikoerper, si:dz180g5.1 antikoerper, LOC100136769 antikoerper, slc4a1 antikoerper, wd1 antikoerper, bnd3 antikoerper, epb3 antikoerper, cd233 antikoerper, empb3 antikoerper, rta1a antikoerper, MGC80391 antikoerper, SLC4A1 antikoerper, BB3 antikoerper, EAT antikoerper, solute carrier family 4 member 1 (Diego blood group) antikoerper, solute carrier family 4 (anion exchanger), member 1 antikoerper, solute carrier family 4 (anion exchanger), member 1a (Diego blood group) antikoerper, Band 3 antikoerper, erythrocyte membrane protein band 4.1 like 3 antikoerper, solute carrier family 4 member 1 (Diego blood group) L homeolog antikoerper, solute carrier family 4 member 1 antikoerper, SLC4A1 antikoerper, Slc4a1 antikoerper, slc4a1a antikoerper, LOC100136769 antikoerper, EPB41L3 antikoerper, slc4a1.L antikoerper, slc4a1 antikoerper

Hintergrund: The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40 kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system.One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.,DI,FR,SW,WD,WR,AE1,CHC,SAO,WD1,BND3,EPB3,SPH4,CD233,EMPB3,RTA1A,SLC4A1,Immunology & Inflammation,CD markers,Cardiovascular,Blood,Blood Cell Antigens,SLC4A1

Gen-ID: 6521

UniProt: P02730