Thymidine Phosphorylase Antikörper
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- Target Alle Thymidine Phosphorylase (TYMP) Antikörper anzeigen
- Thymidine Phosphorylase (TYMP)
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Thymidine Phosphorylase Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- Protein G affinity chromatography
- Immunogen
- Human recombinant full length protein was used as the immunogen for this Thymidine Phosphorylase antibody.
- Klon
- SPM322
- Isotyp
- IgG1
- Top Product
- Discover our top product TYMP Primärantikörper
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- Applikationshinweise
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IP: 1-2 μg/500 μg lysate
IHC (FFPE): 1-2 μg/mL for 30 min at RT
WB: 0.5-1 μg/mL
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Thymidine Phosphorylase antibody to be titered up or down for optimal performance. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.2 mg/mL
- Buffer
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
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- Target
- Thymidine Phosphorylase (TYMP)
- Andere Bezeichnung
- Thymidine Phosphorylase (TYMP Produkte)
- Synonyme
- ECGF antikoerper, ECGF1 antikoerper, MEDPS1 antikoerper, MNGIE antikoerper, MTDPS1 antikoerper, PDECGF antikoerper, TP antikoerper, hPD-ECGF antikoerper, 2900072D10Rik antikoerper, Ecgf1 antikoerper, PD-ECGF antikoerper, Pdgfec antikoerper, typh antikoerper, thymidine phosphorylase antikoerper, thymidine phosphorylase DeoA antikoerper, AMP phosphorylase antikoerper, Thymidine phosphorylase antikoerper, TYMP antikoerper, Tymp antikoerper, deoA antikoerper, Dd586_0614 antikoerper, Kvar_4413 antikoerper, NMAG_RS19330 antikoerper, Snov_1187 antikoerper, Fbal_2856 antikoerper, Ftrac_2071 antikoerper, Intca_1216 antikoerper, ARCVE_RS10415 antikoerper, Sphch_4174 antikoerper, Sinme_3461 antikoerper, METOK_RS06355 antikoerper, Mesop_1831 antikoerper, typh antikoerper
- Hintergrund
- Recognizes a 485 amino acid protein (55 kDa monomer / 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
- Gen-ID
- 1890
- UniProt
- P19971
- Pathways
- Signaling Events mediated by VEGFR1 and VEGFR2
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