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Rekombinanter Thymidine Phosphorylase Antikörper

TYMP Reaktivität: Human, Ratte, Maus IHC, StM Wirt: Kaninchen Monoclonal TYMP-2890R unconjugated Recombinant Antibody
Produktnummer ABIN6939278
  • Target Alle Thymidine Phosphorylase (TYMP) Antikörper anzeigen
    Thymidine Phosphorylase (TYMP)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 70
    • 28
    • 23
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 59
    • 17
    • 1
    Kaninchen
    Klonalität
    • 59
    • 18
    Monoklonal
    Konjugat
    • 34
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Thymidine Phosphorylase Antikörper ist unkonjugiert
    Applikation
    • 51
    • 31
    • 18
    • 15
    • 13
    • 13
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
    Klon
    TYMP-2890R
    Isotyp
    IgG
  • Applikationshinweise

    Positive Control: HUVEC cells. Breast, Bladder, Lung or Kaposi tumors.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    Thymidine Phosphorylase (TYMP)
    Andere Bezeichnung
    TYMP (TYMP Produkte)
    Synonyme
    ECGF antikoerper, ECGF1 antikoerper, MEDPS1 antikoerper, MNGIE antikoerper, MTDPS1 antikoerper, PDECGF antikoerper, TP antikoerper, hPD-ECGF antikoerper, 2900072D10Rik antikoerper, Ecgf1 antikoerper, PD-ECGF antikoerper, Pdgfec antikoerper, typh antikoerper, thymidine phosphorylase antikoerper, thymidine phosphorylase DeoA antikoerper, AMP phosphorylase antikoerper, Thymidine phosphorylase antikoerper, TYMP antikoerper, Tymp antikoerper, deoA antikoerper, Dd586_0614 antikoerper, Kvar_4413 antikoerper, NMAG_RS19330 antikoerper, Snov_1187 antikoerper, Fbal_2856 antikoerper, Ftrac_2071 antikoerper, Intca_1216 antikoerper, ARCVE_RS10415 antikoerper, Sphch_4174 antikoerper, Sinme_3461 antikoerper, METOK_RS06355 antikoerper, Mesop_1831 antikoerper, typh antikoerper
    Molekulargewicht
    55kDa
    Gen-ID
    1890
    UniProt
    P19971
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2
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