This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse Uhrf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of Mouse Uhrf2.
NIRF antikoerper, RNF107 antikoerper, URF2 antikoerper, 2310065A22Rik antikoerper, AI426270 antikoerper, AW214556 antikoerper, D130071B19Rik antikoerper, Nirf antikoerper, ubiquitin like with PHD and ring finger domains 2 antikoerper, ubiquitin-like, containing PHD and RING finger domains 2 antikoerper, ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog antikoerper, UHRF2 antikoerper, Uhrf2 antikoerper, uhrf2.L antikoerper
Hintergrund
E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.