HIF1AN Antikörper (AA 1-349)

Produktnummer ABIN6243664

Produktdetails anti-HIF1AN Antikörper

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Bindungsspezifität: AA 1-349

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HIF1AN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This HIF1AN antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-349 amino acids from human HIF1AN.

Klon: 931CT3-1-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu HIF1AN

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Andere Bezeichnung: HIF1AN (HIF1AN Produkte)

Synonyme: FIH1 antikoerper, 2310046M24Rik antikoerper, A830014H24Rik antikoerper, cb728 antikoerper, id:ibd5139 antikoerper, hypoxia inducible factor 1 alpha subunit inhibitor antikoerper, hypoxia-inducible factor 1, alpha subunit inhibitor antikoerper, hypoxia inducible factor 1, alpha subunit inhibitor antikoerper, hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog antikoerper, HIF1AN antikoerper, Hif1an antikoerper, hif1an antikoerper, hif1an.S antikoerper

Hintergrund: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Molekulargewicht: 40285

UniProt: Q9NWT6

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development