HIF1AN Antikörper

Produktnummer ABIN7239416

Produktdetails anti-HIF1AN Antikörper

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIF1AN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human HIF1AN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HIF1AN

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Andere Bezeichnung: HIF1AN (HIF1AN Produkte)

Synonyme: FIH1 antikoerper, 2310046M24Rik antikoerper, A830014H24Rik antikoerper, cb728 antikoerper, id:ibd5139 antikoerper, hypoxia inducible factor 1 alpha subunit inhibitor antikoerper, hypoxia-inducible factor 1, alpha subunit inhibitor antikoerper, hypoxia inducible factor 1, alpha subunit inhibitor antikoerper, hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog antikoerper, HIF1AN antikoerper, Hif1an antikoerper, hif1an antikoerper, hif1an.S antikoerper

Hintergrund: Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.

Molekulargewicht: 40 kDa

NCBI Accession: NP_060372

UniProt: Q9NWT6

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development